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Detox-N-Cleanse is a 100% vegan Food supplement. Detox-N-Cleanse is a synergistic blend of foods and food extracts intended to help support healthy colon, urinary, metal, and other detoxification. Pollution can be a serious issue [1], so many naturally-minded individuals are justifiably concerned about detoxification.


The outside air is polluted, the indoor air is polluted, water is polluted, and the industrialized food supply is polluted with toxins. There are vehicle exhausts, industrial gases, industrial chemicals, chlorinated-fluoridated-plasticized tap water, molds, pesticides, herbicides, preservatives, radiation, colorings, perfumes, colognes, medications, printer/copier dusts, paints, carpet out-gassing, cleaning supplies, and a host of other pollutants. Even toys are still found containing toxic chemicals (and even those that have supposedly "safe" materials like plastic, can still outgas).


Detoxification from toxins makes a great deal of sense in this chemically-altered modern world.


"The etiology of many neurodegenerative diseases has been only partly attributed to acquired traits, suggesting environmental factors may also contribute. Metal dyshomeostasis causes or has been implicated in many neurodegenerative diseases" [2]. Some believe that heavy metals also predispose people to candidiasis/systemic mycoses and/or intestinal issues [3 -4].


Acerola Cherry is one of the most vitamin C dense Foods [5]. Not only does it have free radical scavenging abilities, it also has been shown to increase the antioxidant abilities of some other foods [6]. "Acerola ... contains bioflavonoids" [6], anthocynins, and quercitin [7]. One study concluded that vitamin C "supplementation provides a protective effect against exercise-induced airway narrowing in asthmatic subjects" [8]. Vitamin C has been used to help detoxify from aluminum, arsenic, cadmium, lead, mercury, nickel, and more [9]. Acerola cherries also contain soluble and insoluble fiber, and such fibers are often part of successful colon cleanses.


Apple Pectin has been shown to support and improve colon health [10-13], and it also provides fiber [13]. Apple pectin exerts "a scavenger effect in the intestinal digestion and portal circulation system as an anti-inflammatory food" [13]. Apple pectin has been successfully given as a radioprotection agent to reduce radiation levels in those affected by Chernobyl [14"15]. It has long been used for those with dyspepsia and other digestive complaints [9].


Bioflavonoids are found in acerola cherry, cilantro, collinsonia, garlic, wheat grass, and other plants. Bioflavonoids,

such as Quercitin dihydrate have long been used for toxicities. Even the PDR admits that quercitin may "have benefit in some allergic conditions, in conditions characterized by capillary fragility, in chronic prostates and in some cancers ... Quercetin is one of several flavonoids that have effects on mast cells and basophils ... it might be useful in some allergies, such as hay fever. Quercetin can help prevent the release of histamine and other mediators of allergies, possibly stabilize cell membranes so that they are less reactive to allergens" [5]. "The major active biological constituents in Citrus herbs are flavonoids, especially hesperidin, naringin and alkaloids, mainly synephrine, with beneficial medical effects on human health" [17]. Quercetin is often advised for those with asthma, allergic rhinitis, or hay fever [18]. Bioflavonoids are sometimes simply called flavonoids. Citrus bioflavonoids have been found to have anti-allergic effects and may be useful to improve symptoms associated with seasonal allergic rhinitis [19].

Chlorella is a special type of algae. Chlorella is often used for heavy metal and other forms of detoxification. It has the ability to absorb mercury, cadmium, arsenic and other heavy metals [9]. The PDR states, "Chlorella ... contains chlorophyll, carotenoids, such as astaxanthin, canthaxanthin, flavoxanthin, loraxanthin, neoxanthin, and violaxanthin. Chlorella also contains the xanthophyll, echinenone ... Chlorella has putative anticarinogenic, immunomodulatory, hypolipidemic, gastric mucosal-protective and detoxification activities .. .In rats, chlorella was found to promote the excretion of dioxin ... Chlorella had demonstrated ability to protect against gamma-radiation, as well as a number of drugs and various toxic chemicals" [5]. Live chlorella has been found to remove lead from waste water [23].

Cilantro Coriandrum sativum is also known as Chinese parsley. It has been found to accelerate the excretion of lead and mercury through urine [24]. It has also been found to remove both inorganic and methyl forms of mercury [25]. Another study concluded that cilantro "has suppressive activity on lead deposition, probably resulting from the chelation of lead by some substances contained in Chinese parsley" [26].

Collinsonia Root is also called stone root and has tonic effects, which may be due to its essential oil and rosmaric acid [16]. It contains a relatively unique bioflavonoid 2,5-dihydroxy-dimethoxyflavone, along with the flavones "baicalein-6,7"dimethyl ether (2), norwogenin-7,8-dimethyl ether (3), and tectochrysin (5-hydroxy-7 -methoxyflavone)" [27]. It is most often used for stomach complaints, hemorrhoids, or constipation [28,29], while its tonic effects within the bowels help maintain a state of calm (and also helps the bowels function more naturally). It is "[o]f reputed value in Varicose Vein conditions and for Hemorrhoids" [30]. It has long been used in combination with ox bile to help support bile flow and deal with indigestion [31]. Collinsonia root "is used for calculi, kidney stones, urea (bladder semolina), bladder inflammation, dropsy and gastrointestinal disorders" [32].

Garlic has been used to help detoxify from aluminum, arsenic, beryllium, lead, mercury, and nickel [9]. "Garlic is used internally as an adjuvant to dietetic measures for elevated lipid levels. The herb is also used for prevention of age-related vascular changes and arteriosclerosis". "Garlic contains compounds that help prevent nitrites-common substances found in foods as well as a variety of every day pollutants-from transforming themselves into nitrosamines, harmful compounds that can trigger cancerous changes in the body" [8]. Garlic has anti-oxidant effects which means it can reduce toxicity associated free-radical damage. "Garlic contains the trace elements germanium and selenium, which have been thought to play a role in improving host immunity and 'normalizing' the oxygen utilization in neoplastic cells" [18]. Garlic compounds have been found to inhibit lipid peroxidation, which "is considered to be one of the main features of aging in liver cells" [18].

Methionine is an essential amino acid and a precursor to I-cysteine [5]. "L-methionine may protect against the toxic effects of hepatoxins, such as acetaminophen" and "methotrexate" [5]. Methionine is a powerful antioxidant... which inactivates free radicals ... As levels of toxic substances in the body increases, the need for methionine increases" [18]. Much of the methionine in the body is converted into S-adenosylmethlonine, which is an active agent for many enzymatic reactions. Various methionine-containing compounds have been used to help detoxifY from aluminum, arsenic, cadmium, ethanol, lead, molybdenum, mercury, nickel, and thimerosal [9,33]. A study involving chickens revealed that the odor, hence contents, of fecal matter is influenced by methionine supplementation [34]. It has been speculated that people with diseases such as Alzheimer's and Parkinson's would benefit from methionine-containing compounds [35].

Modified Citrus Pectin (from inner citrus peel) is one of the most effective known natural detoxifiers. It has been found to be effective for many heavy metals [36]. A urinary output study found that it can reduce toxic metals like lead and cadmium in people with supposed "normal" levels of those toxins [37]. Additionally, has reduced lead in children with toxic lead levels [38]. It has been claimed that, "Even though modified citrus pectin is strong enough to soak up toxins and heavy metals in your system like a sponge, it is also gentle on your system. Not a single person in these human trials reported any side effects. Modified citrus pectin is one of the safer forms of toxin removal because it does NOT deplete essential minerals your body needs. So while it eliminates toxic metals and pesticides like lead, cadmium, and mercury, it doesn't deplete your body of zinc, calcium, or magnesium" [39]. Pectin has been used to help detoxify from mercury and nickel [9]. "Heavy metals like mercury, lead, cadmium and arsenic have been implicated in a wide number of health problems, including arteriosclerosis, hypertension, multiple sclerosis, impaired immune function, and an overgrowth of Candida albicans. Research exists showing the effectiveness of pectin in chelating (binding to) heavy metals and removing them from the body" [3]. It has been studied for prostate issues "for further chemopreventive and chemotherapeutic analysis in vivo"[40]. Detox-N-Cleanse contains PectaSol" (which is a registered trademark of EcoNugenics, Inc.) as this particular version of modified citrus pectin has been perhaps the most extensively tested for efficacy in detoxification.

N-Acetyl-L-Cysteine (NAC) is the delivery form of l-cysteine [5], which is an amino acid. It is a reducing agent that

has proven antioxidant activity for scavenging free radicals [5]. "Cysteine helps detoxifY harmful toxins and protect the body from radiation damage. It is one of the best free radical destroyers. N-acetylcysteine aids in preventing side effects from chemotherapy and radiation therapy" [18]. NAC is sometimes used "for boosting intracellular glutathione levels" [41] and is more effective than even glutathione itself to do that [18]. At high doses, it has been found to be an antidote for acetaminophen poisoning and Amanita phalloides intoxification" [5]. Various cysteine-containing compounds have been used to help detoxifY from aluminum, arsenic, cadmium, lead, mercury, and nickel [9,42,43]. NAC seems to be able to reduce nitrates and serum levels of the medication carbamazepine [5]. NAC has "antioxidant properties and chelating ability" and a rat study found it had protective effects against lead toxicity for the kidneys [42]. According to one study, "N-acetylcysteine prevents memory deficits, the decrease in acetylcholinesterase activity and oxidative stress in rats exposed to cadmium" [44].

Slippery Elm is an herb long used for successful colon cleansing. "The main focus of Slippery Elm is the GI Tract where it can provide nutrition, a soothing coat over stomach and intestinal ulcers, soothing the colon ... and to absorb foul gases [45]. "Slippery elm contains large amounts of mucilage, which will coat the surface of the mucous membranes or surface of wounds and sores when it comes in contact with water ... Slippery elm has been successfully used as a demulcent and emollient" [16]. "It has also been known to 'draw out' toxins, boils, splinters, and other irritants" [46]. Historically, it has been used "in the treatment of gastritis and gastric or duodenal ulcers" [16]. Some believe slippery elm is "effective for protection against stomach ulcers, colitis, diverticulitis, gut inflammation, and acidity. Slippery elm is also useful for diarrhea, constipation, hemorrhoids, irritable bowel syndrome, and to expel tapeworms" [46].

Wheat Grass Triticum aestivum is a highly akalizing Food [47]. It has long been used to re-invigorate health, and for other complaints of fatigue [48]. Wheat grass is rich in chlorophyll [5]. Wheat grass has been used to help detoxify from fluoride and as well as other toxic substances [5,9]. "Wheat grass is used as a general health tonic and ... a ... beneficial role of wheat grass in ameliorating hyperlipidemia and the associated oxidative stress" [49]. It may help with certain types of IBS (irritable bowel syndrome) [5,50].

CNN reported about a small American study recently found 232 unnatural chemicals in the umbilical cords of newborn human infants [51]. We are living in an age where there are too many chemicals and other toxins in the environment.

Detox-N-Cleanse contains natural vitamin C from acerola cherries (and no isolated ascorbic acid), herbs, and other plant extracts that support healthy detoxification. It is the choice for natural health professionals interested in 100% Food detoxification.



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[8] Tecklenburg SL, Mickleborough TD, Fly AD, Bai Y, Stager JM. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respir Med. 2007 Aug;101(8):1770-8

[9] Thiel R. Serious Nutrition for Health Care Professionals, 3rd ed. Center for Natural Health Research, Arroyo Grande (CA), 1997

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[12] Liu L, Li Y, Niu Y, Sun Y, Guo Z, Li Q, Li C, Feng J, Cao S, Mei Q. An App]e Oligoga]actan Prevents against Inflammation and Carcinogenesis by Targeting LPSfTLR4/NF-{kappa) B Pathway inA Mouse Model of Colitis-Associated Colon Cancer. Carcinogenesis. 2010Apr ]6. [Epub ahead of print]

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[14] Nesterenko VB, Nesterenko AV Decorporation ofChemoby] radionuclides. Ann N Y Acad Sci. 2009 Nov;1181:303-1O

[15] Bandazhevskaya GS, Nesterenko VB, Babenko VI, Yerkovich TV, Bandazhevsky YI. Re]ationship between caesium (I 37Cs) load, cardiovascular symptoms, and source of food in 'Chemobyl' children -- preliminary observations after intake of oral apple pectin. Swiss Med WkJy. 2004 Dec ]8;134(49-50):725-9

[]6] Gruenwald J, Brendler T, Jaenicke C, editors. PDR for Herbal Medicines, 4th ed. Thomson, Montvale (NJ), 2007

[17] Ding L, Luo X, Tang F, Yuan J, Liu Q, Yao S. Simultaneous determination of flavonoid and a]kaloid compounds in Citrus herbs by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct] ;857(2):202-9

[] 8] Balch JF, Balch PA. Prescription for Nutritional Healing. Avery Publishing, Garden City (NY), ] 997

[19] Tanabe S, Kinuta Y, Yasumatsu H, Takayanagi M, Kobayashi S, Takido N, Sugiyama M. Effects of Citrus unshiu Powder on the Cytokine Ba]ance in Peripheral B]ood Mononuclear Cells ofPatieuts with Seasonal Allergic Rhinitis to Pollen. Biosci. Biotechnol. Biochem. 2207, 71 (] 1),2852-2855

[20] Mohapatra DK, Mohanty L, Mohanty RC, Mohapatra PK. Biotoxicity of mercury to Ch]orella vulgaris as influenced by amino acids. Acta Bioi Hung. 1997;48(4):497-504 [2]] Huckabee JW, B]aylock BG. Transfer of mercury and cadmium from terrestrial to aquatic ecosystems. Adv Exp Med BioI. ] 973;40:] 25-60

[22] Levy JL, Stauber JL, Adams MS, Maher WA, Kirby JK, Jolley Dr. Toxicity, biotransformation, and mode of action of arsenic in two freshwater microalgae (Ch]orella sp. and Monoraphidium arcuatum). Environ Toxicol Chem. 2005 Oct;24(10):2630-9

[23] Kumar R, Goya] D. Comparative biosorption ofPb2+ by live alga] consortium and immobilized dead biomass from aqueous solution. Indian J Exp BioI. 2009 Aug;47(8):690-4

[24] Omura Y, Beckman SL. Role of mercury (Hg) in resistant infections & effective treatment of Chlamydia trachomatis and Herpes family viral infections (and potential treatment for cancer) by removing localized Hg deposits with Chinese parsley and delivering effective antibiotics using various drug uptake enhancement methods. Acupunct Electrother Res. 1995 Aug-Dec;20(3-4): 195-229

[25] Kanmasagar D, Krishna MV, Rao SV, Arunachalam J. Removal and preconcentration of inorganic and methyl mercury from aqueous media using a sorbent prepared from the plant Coriandrum sativum. J Hazard Mater. 2005 Feb 14;1 ]8(1-3):133-9

[26] Aga M, Iwaki K, Ueda Y, Ushio S, Masaki N, Fukuda S, Kimoto T, Ikeda M, Kurimoto M. Preventive effect ofCoriandrum sativum (Chinese parsley) on ]ocalized lead deposition in ICR mice. J Ethnopharmacol. 2001 Oct;77(2-3):203-8

[27] Stevens JF, Ivancic M, Deinzer ML, Wollenweber E. A novel 2-hydroxyflavanone from collinsonia Canadensis. J Nat Prod. 1999 Feb;62(2):392-4 [28] Cotran RS, Kumar V, Collins T. Robbins Patho]ogoical Basis for Disease, 6th ed. WE Saunders, Phil, 1999

[29] Scalzo R. Naturopathic Handbook of Herbal Formulas, 3rd ed. Kivaki Press, Durango (CO), ] 994

[30] Lee R. Collinsonia. In Product Bulletins, circa 1950

[31] Lee R. Cholacol. In Product Bulletins, circa] 950

[32] Gruenwald J, Brend]erT, Jaenicke C, eds. PDR for Herba] Medicine, 2nd ed. Medical Economics, Montvale (NJ), 2000

[33] Wa]y M, Olteanu H, Banerjee R, Choi SW, Mason JB, Parker BS, Sukumar S, Shim S, Sharma A, Benzecry'JM, Power-Charnitsky VA, Deth RC. Activation of methionine synthase by insulin-]ike growth factor-I and dopamine: a target for neurodeve]opmental toxins and thimerosal. Mo] Psychiatry. 2004 Apr;9( 4):358-70

[34] Chavez C, Coufal CD, Carey JB, Lacey RE, Beier RC, Zahn JA. The impact of supplemental dietary methionine sources on volatile compound concentrations in broiler excreta. Poult Sci. 2004 Jun;83(6):901-10

[35] Newman PE. Alzheimer's disease revisited. Med Hypotheses. 2000 May;54(5):774-6

[36] Eliaz I, Weil E, Wi]k B. Integrative medicine and the role of modified citrus pectin/alginates in heavy metal chelation and detoxification--five case reports. Forsch Komplementmed. 2007 Dec;14(6):358-64

[37] Eliaz I, Hotchkiss AT, Fishman ML, Rode D. The effect of modified citrus pectin on urinary excretion of toxic elements. Phytother Res. 2006 Oct;20(lO):859-64

[38] Zhao ZY, Liang L, Fan X, Yu Z, Hotchkiss AT, Wilk BJ, Eliaz I. The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead ]evels. Altem Ther Health Med. 2008 Jul-Aug;]4(4):34-8

[39] Sears A. 6-day citrus detox. Doctor's House Call, June 28, 2010

[40] Yan J, Katz A. PectaSol-C modified citrus pectin induces apoptosis and inhibition of proliferation in human and mouse androgen-dependent and- independent prostate cancer cells. Integr Cancer Ther. 2010 Jun;9(2):I97-203

[4]] McCarty MF. Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease. Med Hypotheses. 20]0 Jun;74(6):1055-8 [42] Wang L, Wang Z, Liu J. Protective effect ofN-acetylcysteine on experimental chronic lead nephrotoxicity in immature female rats. Hum Exp Toxicol. 20]0 Jul;29(7):581-91

[43] Triimpler S, Nowak S, Meermann B, Wiesmiiller GA, Buscher W, Sperling M, Karst U. Detoxification of mercury species-an in vitro study with antidotes in human whole blood. Ana] Bioanal Chern. 2009 Nov;395(6): I 929-35

[44] Gon,alves JF, Fiorenza AM, Spanevello RM, Mazzanti CM, Bochi GV, Antes FG, Stefanello N, Rubin MA, Dressler VL, Morsch VM, Schetinger MR. N-acetylcysteine prevents memory deficits, the decrease in acetylcholinesterase activity and oxidative stress in rats exposed to cadmium. Chern BioI Interact. 2010 Jun 7; 186(1 ):53-60

[45] Ritchason J. The Little Herb Encyclopedia, 3rd ed. Woodland Health Books, Pleasant Grove (UT), 1995

[46] Burnham TH, et aI, editors. The Review of Natural Products. Facts and Comparisons, St. Louis. 200]

[47] Null G. The Complete Encyclopedia of Natural Healing. Kensington Books, NY, 1998

[48] Duke l.A. The Green Phurmacy. Rodale Press, Emmaus (PA), 1997

[49] Sethi J, Yadav M, Dahiya K, Sood S, Singh V, Bhattacharya SB. Antioxidant effect of Triticum aestivium (wheat grass) in high-fat diet-induced oxidative stress in rabbits. Methods Find Exp Clin Pharmacol. 20] 0 May;32( 4):233-5

[50] Langmead L, Rampton DS. Review article: complementary and alternative therapies for inflammatory bowel disease. A]iment Pharmacol Ther. 2006 Feb 1;23(3):34]-9 [5]] Gupta S. Toxic Childhood. CNN, August 7, 2010

Some of these studies (or citations) may not conform to peer review standards, therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the USFDA, Health Canada, or other international governmental regulatory agency. All products from Food Research International are nutritional and are not intended for the treatment or prevention of any medica] condition.




Advanced Joint Complex
Aller-Lung Support
Arginase Bladder
B Stress Complex
C Complex
Cal-Mag Complex
Calcium Complex

Complete Ear Health
Complete Eye Health
Smell & Taste
D Complex
GB Support
Green Vegetable Alkalyzer
Hematic Formula
Herbal Antioxidant
High Stress Adrenal
Inositol Complex
Le Feminine Advantage
Magnesium Complex
Metabolic Thyro

Omega 3 / EPA / DHA
Restful Mind Support
Selenium E Complex
Serious Brain Enhancer
Simply Glandulars
Vegetarian Adrenal
Vegetarian Thyro
Vegetarian Tryptophan
Vegetarian Tyrosine
Vita B-6, B-12, & Folate
Vitamin Mineral
Wheat Germ Oil
Zinc Complex



Important Note:
The information presented herein by The Natural Path Botanicals is intended for educational purposes only. These statements have not been evaluated by the FDA and are not intended to diagnose, cure, treat or prevent disease. Individual results may vary, and before using any supplements, it is always advisable to consult with your own health care provider.

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