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Coenzyme Q10
In 1985, Folkers et al. found that patients with heart failure had a deficiency of CoQ10 in their myocardial cells and that the degree of deficiency correlated with the clinical severity of disease (3). In 1998, Keith et al. published a study demonstrating increased oxidative stress in patients with congestive heart failure (4). Since then, it has been postulated that depletion of CoQ10 may contribute to heart failure and that it may be useful in treating cardiac disease. In fact, it has been proposed that CoQ10 may be beneficial in a number of different disease, including heart failure, angina pectoris, cardiac arrhythmias, periodontal disease, immune disorders, neurological disease, obesity, diabetes mellitus, and cancers including breast and prostate (5). Karl Folkers takes the position that the dominant source of CoQ10 in man is biosynthesis. This complex, 17 step process, requiring at least seven vitamins (vitamin B2 - riboflavin, vitamin B3 - niacinamide, vitamin B6, folic acid, vitamin B12, vitamin C, and pantothenic acid) and several trace elements, is, by its nature, highly vulnerable. Karl Folkers argues that suboptimal nutrient intake in man is almost universal and that there is subsequent secondary impairment in CoQ10 biosynthesis. This would mean that average or "normal" levels of CoQ10 are really suboptimal and the very low levels observed in advanced disease states represent only the tip of a deficiency "ice berg". It has been proposed that CoQ10 may be beneficial in a number of different disease, including heart failure, angina pectoris, cardiac arrhythmias, periodontal disease, immune disorders, neurological disease, obesity, diabetes mellitus, and cancers including breast and prostate. Its use is supposedly widespread in Japan and Italy. Approximately 30 Japanese reports describe the positive effects of CoQ10 on the heart. CoQ10 shows a moderate variability in its absorption, with some patients attaining good blood levels of CoQ10 on 100 mg per day while others require two or three times this amount to attain the same blood level. CoQ10 is fat-soluble and absorption is significantly improved when it is chewed with a fat-containing food.
Statin Drug Use and CoQ10 Other side effects of statin drugs are heart failure, headaches, liver damage, nausea, fever, muscle pain (myopathy), muscle breakdown (rhabdomvolvsis), sexual dysfunction, memory loss, personality changes, irritability, dizziness, cognitive impairment, cancer, pancreatic degeneration, depression.
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Coenzyme Q10 was first isolated from beef heart
in 1957 by Dr. Frederick Crane at the University of
Wisconsin. Its structure was elucidated only a year
later. The name "Coenzyme Q" was chosen because the
molecule was proved to be a quinone (a family of
molecules essential for generating energy in organisms
that consume oxygen). The 10 comes from the number of
isoprene units in the tail of the molecule (2). Since
its discovery over forty years ago, much research has
been conducted to determine the role of CoQ10 in human
health and disease. CoQ10 is found in highest
concentrations in the mitochondria of the heart, liver,
and kidney; organs whose cells are constantly working.
